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A vhh antibody (or nanobody) is the antigen binding fragment of heavy chain only antibodies The vhh domain represents the absolute smallest antibody fragment necessary to specifically bind an antigen with exceptionally high affinity. Discovered nearly 25 years ago, they have been investigated for their use in clinical therapeutics and immunodiagnostics, and more recently for.
These proteins consist of framework regions and three highly variable loops Nanobody molecules retain the antigen binding region of the heavy chain domain of a conventional antibody, but do not have the other light variable chain domains (figure 1). Nanobodies are antibodies with a single variable domain located on a heavy chain, also known as vhh antibodies
Nanobodies are often seen as an alternative to conventional antibodies, and have significant differences in both production and use that influence their suitability.
In the field of therapeutic antibodies, vhh nanobodies are expected to become the next generation of targeted therapeutic tools, particularly for treating cancers and inflammatory diseases. What is a vhh antibody Vhh antibodies, or nanobodies, were discovered in camelid species such as llamas and alpacas
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