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Your test results show a high level of kappa free light chains in your blood, with a very high free light chain ratio of 101.55 (normal is around 0.26 to 1.65) I have consistently high kappa lambda numbers (about 19 times normal) and the oncologist says that when the numbers are reasonably stable over such a lengthy period, they rarely turn into anything! This means there's a much larger amount of kappa chains compared to lambda chains, which is not typical
Having high free kappa (kappa light chains) and high free lambda (lambda light chains) can be an indicator of certain health conditions. It may also be used to diagnose other conditions affecting the cells in your bone marrow. Providers call unlinked proteins in your blood “free light chains.” your blood contains two types of free light chains
Kappa and lambda light chains
It’s normal to have some of both But some people have abnormally high or low levels of one or both types of free light chains in their blood. Free light chains will normally be present in the blood at low levels, but with a normal kappa/lambda ratio Increased kappa free light chains and an increased kappa/lambda ratio may be seen with plasma cell disorders that produce excess monoclonal kappa light chains.
Understanding kappa and lambda free light chains Our body’s defense mechanism against infections includes the production of immunoglobulins, or antibodies, by plasma cells These antibodies consist of heavy chains and two types of light chains A free light chains test measures the amount of lambda and kappa free light chains in your blood
If the amount of free light chains is higher or lower than normal, it may be a sign of a disorder of the plasma cells.
When abnormalities are detected, such as an increased kappa free light chain level or a skewed kappa/lambda ratio, it may hint towards a plasma cell disorder Recognizing the differences between kappa and lambda chains is crucial for proper diagnosis. This test is used to help diagnose a type of cancer called multiple myeloma
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