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This research provides insights into the evolutionary complexity and heterogeneity of malignant epithelial populations in lymph node metastatic sites of luad Malignant epithelial cells were identified via inferred copy number variation (cnv) profiles. It also presents a scoring system based on prognostic indicators, which serves as a reliable tool for forecasting patient survival outcomes
We uncovered 25 tim states, most of which were reproducibly found across patients Tumors from different patients display large heterogeneity in cellular composition, chromosomal structure, developmental trajectory, intercellular signaling network and phenotype dominance. To facilitate translational research of these populations, we also profiled tims in mice.
In lung cancer, dtp studies have mainly been conducted with cell line models
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